Insulin Exocytosis
Description
Secretory insulin granule exocytosis is a highly regulated process involving vesicle targeting, priming, and membrane fusion. To carry out these procedures, SNAREs and Rabs are essential. The exocytotic process in pancreatic β-cells depends on the proteins anchored on the membrane of secretory vesicles, v-SNAREs Synaptobrevin (VAMP-2) and Synaptotagmin, as well as the proteins associated with the plasma membrane, t-SNAREs syntaxin-1 and SNAP-25.
Acknowledgements
References
Omar-Hmeadi, M., Idevall-Hagren, O. Insulin granule biogenesis and exocytosis. Cell. Mol. Life Sci. 78, 1957–1970 (2021). https://doi.org/10.1007/s00018-020-03688-4
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