Inflammation through pyroptosis in Intramyocardial Hemorrhage
Description
In IMH, hydroxy ferrihydrite has been found to induce a cascade of events causing chronic inflammation due to rupture of downstream arteries post myocardial hemorrhage. This cascade activates the NLRP3 inflammasome and leads to pyroptotic pathways. This figure describes how macrophages are affected by rupture from the ferric crystals leading to continued inflammation.
Acknowledgements
References
Kali, Avinash et al. “Persistent Microvascular Obstruction After Myocardial Infarction Culminates in the Confluence of Ferric Iron Oxide Crystals, Proinflammatory Burden, and Adverse Remodeling.” Circulation. Cardiovascular imaging vol. 9,11 (2016): e004996. doi:10.1161/CIRCIMAGING.115.004996
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