Inflammasome Activation Leading to Pyroptosis
Description
Inflammasomes are cellular sensors that detect harmful signals, like pathogens or stress. When activated, they trigger a cascade of events leading to pyroptosis, a form of programmed cell death. This process involves the assembly of inflammasome complexes, activation of pro-caspases, cleavage of gasdermin proteins, and formation of membrane pores. These pores disrupt the cell membrane, causing it to burst and release inflammatory mediators like IL-1β and IL-18.
Acknowledgements
Merideth Krevosky
References
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