Impact of Hyaluronan on GBM Cells
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
Hyaluronan impacts glioblastoma cells by interacting with its receptors, CD44 and RHAMM, which in turn interact with other receptors, such as EGFR. This causes increasing migration, invasion, and proliferation as well as radio and chemotherapy resistance. Moreover, glioblastoma cells secrete HA, which forms a halo that induces dendritic cell death acts as an immunoprotective barrier.
Acknowledgements
References
Matías Pibuel. (2020) Glioblastoma and hyaluronan.
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