Immune checkpoint proteins (CTLA-4, PD-1 and PD-L1) and their impact on T cell activity
Description
A visualisation of the role of immune checkpoint proteins and the role of immune checkpoint inhibitors in enhancing T cell response. The immune checkpoint inhibitors inhibit T cell function which allows for tumour cell growth. Immune checkpoint inhibitors prevent this action and allow for tumour cell death. The immune checkpoint proteins are Cytotoxic T Lymphocyte Associated protein - 4 (CTLA-4), programmed cell death protein- 1 (PD-1) and Programmed death ligand - 1 (PD-L1).
Acknowledgements
References
NATIONAL CANCER INSTITUE (2022) Immune checkpoint inhbitors. Available at:
Immune Checkpoint Inhibitors - NCI (cancer.gov) (Acessed: 15 February 2024)
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