IDH Mutant in Cancer Cells
Description
This figure illustrates the role of IDH enzymes in a healthy condition vs cancer condition. In normal cells, IDH1 & IDH2 enzymes catalyze the conversion of isocitrate to alpha-ketoglutarate, which plays an important role in histone demethylation and gene regulation. In cancer cells, IDH enzymes are mutated, leading to 2-hydroxyglutarate (2-HG) accumulation in the cell. 2-HG inhibits the action of alpha-ketoglutarate, leading to histone hyper-methylation and disregulated genes.
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