Hypothetical mechanism to explain morphine's enhanced analgesic effects
Description
Hypothetical gain of function mutation in the N-Type voltage-gated calcium channels could increase morphine's analgesic effects by increasing these channels' permeability to Ca leading to so much NT release that the RRP gets depleted so larger depolarizing currents because now vesicles need to migrate to the active zone before they can be released. Since morphine causes hyperpolarization of the cell, NT release would be even further suppressed. If this persists, it could eventually lead to LTD.
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