Hypothalamic-Pituitary-Adrenal (HPA) Axis Dysregulation in PTSD
Description
Individuals with PTSD tend to display sustained or elevated levels of CRH in response to stress or trauma, leading to a blunted ACTH response to CRH stimulation, decreased secretion of ACTH, and impaired release of cortisol. The lower-than-normal cortisol levels, known as hypocortisolism, further dysregulate the negative feedback mechanism of the HPA axis. Individuals with PTSD often exhibit hypocortisolism, heightened negative feedback sensitivity in the HPA axis.
Acknowledgements
References
Yehuda, R. (2006). Advances in understanding neuroendocrine alterations in PTSD and their therapeutic implications. Annals of the new York Academy of Sciences, 1071(1), 137-166.
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