HIV infection impairs the host response to Mycobacterium tuberculosis infection
Description
Tuberculosis is the leading cause of death for people living with HIV (PLWH). We hypothesized that altered functions of innate immune components in the human alveolar lining fluid of PLWH (HIV-ALF) drive susceptibility to Mycobacterium tuberculosis (M.tb) infection. Primary human macrophages infected with M.tb exposed to HIV-ALF were significantly less capable of controlling the infection, which was reversed by SP-D replenishment in HIV-ALF.
Acknowledgements
References
Anwari Akhter, Juan I. Moliva, Abul K. Azad, Angélica Olmo-Fontánez, et al. HIV infection impairs the host response to Mycobacterium tuberculosis infection by altering surfactant protein D function in the human lung alveolar mucosa, Mucosal Immunology, 2024.
Angélica M. Olmo-Fontánez et al. Human alveolar lining fluid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells, Mucosal Immunology, 2024.
Juan I Moliva, Michael A Duncan, Angélica Olmo-Fontánez, Anwari Akhter, et al. The Lung Mucosa Environment in the Elderly Increases Host Susceptibility to Mycobacterium tuberculosis Infection, The Journal of Infectious Diseases. 2019
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