Make scientific figures in minutes

Create publication-quality figures with pre-made icons and templates, all from BioRender's web-based scientific illustration software

USE TEMPLATES IN THE APP

Try a synonym, or sign up to suggest a template from the app.

An editable high resolution scientific image depicting HIF-1a Oncogenic pathway under hypoxic conditions

HIF-1a Oncogenic pathway under hypoxic conditions

Description

In normoxic conditions, HIF-1α is degraded by the von Hippel-Lindau (VHL) E3 ubiquitin ligase complex. But under hypoxia, this breakdown process is inhibited, allowing HIF-1α to form complex with HIF-1β, creating a powerful molecular duo. This duo binds to specific DNA regions termed HREs. Once bound, the complex activates genes that are involved in tumorigenesis, such as cell proliferation, energy metabolism, angiogenesis, immune evasion, metastasis and drug resistance.

Acknowledgements

References

Yan Zhao, Cheng Xing, Yating Deng, Can Ye, Hongling Peng, HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies, Genes & Diseases, Volume 11, Issue 1, 2024, Pages 234-251, ISSN 2352-3042.
Get started with this template for free

Don’t start from scratch.

Create professional scientific illustrations quickly and easily, even without any design expertise
  • Get started with a huge library of editable icons and templates such as common biological pathways, anatomy, or genetics.
  • Create figures that effectively communicate your research in half the time using our editable icons.
  • Use our PDB tool to quickly generate and customize protein structures
Get started now
example of using the icon library

Use BioRender for...

This is some text inside of a div block.