Gut-associated IgA+ immune cells regulate obesity-related insulin resistance
Description
Graphical abstract of research article:
- B cell derived IgA is a crucial antibody that ensures mutualism with gut commensals.
- High fat diet feeding in mice compromises IgA production.
- IgA deficiency results in gut microbial dysbiosis, worsened intestinal permeability, inflammation and metabolic disease.
Acknowledgements
References
Luck H, Khan S, Kim JH, Copeland JK, Revelo XS, Tsai S, Chakraborty M, Cheng K, Tao Chan Y, Nøhr MK, Clemente-Casares X, Perry MC, Ghazarian M, Lei H, Lin YH, Coburn B, Okrainec A, Jackson T, Poutanen S, Gaisano H, Allard JP, Guttman DS, Conner ME, Winer S, Winer DA. Gut-associated IgA+ immune cells regulate obesity-related insulin resistance. Nat Commun. 2019 Aug 13;10(1):3650. doi: 10.1038/s41467-019-11370-y. PMID: 31409776; PMCID: PMC6692361.
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