Glial Dystrophin associated Protein Complex
Description
In glial cells, the DAPC comprises on the cytosolic side the Dp71 isoform of dystrophin, α-dystrobrevin, and α1-syntrophin. Dystrophin anchors to the transmembrane dystroglycan complex (α and β1), and α1-syntrophin provides anchorage for aquaporins and ion channels to the membrane. Finally, on the extracellular side, the dystroglycan complex is linked to the α2-laminin/agrin complex, ensuring binding to the basal lamina.
Acknowledgements
References
Jorgacevski, J., R. Zorec, and M. Potokar. 2020. Insights into Cell Surface Expression, Supramolecular Organization, and Functions of Aquaporin 4 Isoforms in Astrocytes. Cells. 9.
Moukhles, H., and S. Carbonetto. 2001. Dystroglycan contributes to the formation of multiple dystrophin-like complexes in brain. J Neurochem. 78:824-834.
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