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An editable high resolution scientific image depicting GABRG2 HUMAN 3D STRUCTURE

GABRG2 HUMAN 3D STRUCTURE

Description

The human GABRG2 protein, a subunit of gamma-aminobutyric acid (GABA) receptors, plays a crucial role in the central nervous system. This study focuses on the structural characterization and functional role understanding of the GABRG2 protein. This understanding sheds light on the protein's functional implications in neural transmission and its potential as a drug target in therapeutic interventions.

Acknowledgements

References

1-)Shen D., et al. De novo GABRG2 mutations associated with epileptic encephalopathies. Brain. 2016, 140(1):49-67. PubMed ID: 27864268 2-)Zou F., et al. Expanding the phenotypic spectrum of GABRG2 variants: a recurrent GABRG2 missense variant associated with a severe phenotype. Journal of neurogenetics. 2017, 31(1-2):30-6. PubMed ID: 28460589 3-)Kang J.Q and Macdonald R.L. Molecular pathogenic basis for GABRG2 mutations associated with a spectrum of epilepsy syndromes, from generalized absence epilepsy to dravet syndrome. JAMA Neurology. 2016, 73(8):1009-16. PubMed ID: 27367160, 4-)Dixit A.B., et al. Mutations in GABRG2 receptor gene are not a major factor in the pathogenesis of mesial temporal lobe epilepsy in Indian population. Annals of Indian Academy of Neurology. 2016, 19(2):236. PubMed ID: 27293336 5-)Dixit A.B., et al. Mutations in GABRG2 receptor gene are not a major factor in the pathogenesis of mesial temporal lobe epilepsy in Indian population. Annals of Indian Academy of Neurology. 2016, 19(2):236. PubMed ID: 27293336
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