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An editable high resolution scientific image depicting Function of macrophage in atherosclerosis

Function of macrophage in atherosclerosis

Description

Macrophages play a crucial role in various aspects of atherosclerosis development, including lipid metabolism, inflammatory responses, the formation of necrotic cores, and plaque instability. Their direct roles of macrophages involve the formation of foam cells, apoptotic cells, and inflamed cells. Indirect roles, such as contributing to CD4+ T cell activation in the atherosclerotic process

Acknowledgements

References

1. Arora, S., Dev, K., Agarwal, B., Das, P., & Syed, M. A. (2018). Macrophages: Their role, activation and polarization in pulmonary diseases. Immunobiology, 223(4-5), 383–396. https://doi.org/10.1016/j.imbio.2017.11.001. 2. Blagov, A. V., Markin, A. M., Bogatyreva, A. I., Tolstik, T. V., Sukhorukov, V. N., & Orekhov, A. N. (2023). The Role of Macrophages in the Pathogenesis of Atherosclerosis. Cells, 12(4), 522. https://doi.org/10.3390/cells12040522. 3. Bobryshev, Y. V., Ivanova, E. A., Chistiakov, D. A., Nikiforov, N. G., & Orekhov, A. N. (2016). Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis. BioMed research international, 2016, 9582430. https://doi.org/10.1155/2016/9582430. 4. Chistiakov, D. A., Bobryshev, Y. V., & Orekhov, A. N. (2016). Macrophage-mediated cholesterol handling in atherosclerosis. Journal of cellular and molecular medicine, 20(1), 17–28. https://doi.org/10.1111/jcmm.12689. 5. Fatkhullina, A. R., Peshkova, I. O., & Koltsova, E. K. (2016). The Role of Cytokines in the Development of Atherosclerosis. Biochemistry. Biokhimiia, 81(11), 1358–1370. https://doi.org/10.1134/S0006297916110134. 6. Gisterå, A., & Hansson, G. K. (2017). The immunology of atherosclerosis. Nature reviews. Nephrology, 13(6), 368–380. https://doi.org/10.1038/nrneph.2017.51
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