Formation and Clearance of Immune Complexes (IC)
Description
Immune complexes (ICs) are formed when soluble antigens bind to antibodies. Depending on the amounts of antigen and antibody, small, intermediate or large ICs can be formed.
Small ICs are bound by Fc receptors on phagocytes like macrophages and phagocytosed or filtered by the kidneys into the urine. Large ICs activate complement and are removed in the spleen. Intermediate ICs that are too large to be filtered and too small to activate complement are deposited in vessels, causing inflammation.
Acknowledgements
References
Theofilopoulos, A. N., & Dixon, F. J. (1980). The biology and detection of immune complexes. In F. J. Dixon & H. G. Kunkel (Eds.), Advances in Immunology (Vol. 28, pp. 89-220). Academic Press. https://doi.org/10.1016/S0065-2776(08)60800-7
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