Folate Transporter Trafficking of CDNs

Description

Mechanistic pathway of CDN trafficking via folate transporters (RFC, PCFT) and STING activation.

Acknowledgements

References

Decout, A., Katz, J.D., Venkatraman, S. et al. The cGAS–STING pathway as a therapeutic target in inflammatory diseases. Nat Rev Immunol 21, 548–569 (2021). https://doi.org/10.1038/s41577-021-00524-z Luteijn RD, Zaver SA, Gowen BG, Wyman SK, Garelis NE, Onia L, McWhirter SM, Katibah GE, Corn JE, Woodward JJ, Raulet DH. SLC19A1 transports immunoreactive cyclic dinucleotides. Nature. 2019 Sep;573(7774):434-438. doi: 10.1038/s41586-019-1553-0. Epub 2019 Sep 11. Erratum in: Nature. 2020 Mar;579(7800):E12. PMID: 31511694; PMCID: PMC6785039.

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