Flavonoids modulate redox metabolism pathways in cancer.
Description
Flavonoids interact with NRF2, activating HO-1, NQO1, IDH1, ME1. Flavonoids inhibit HIF1A, reducing GLUT1 and glycolytic enzymes (PDK1, HK2, and PKM2), increasing the TCA cycle and not allowing the transformation of pyruvate into lactate. Flavonoids inhibit mTOR pathway. Que: Quercetin; Epi: Epigallocatechin, Kae: Kaempferol; Myr: Myricetin; Que: Quercetin; Api: Apigenin; Gen: Genistein; Dai: Daidzein; Lut: Luteolin; Nar: Naringenin; Tax: Taxifolin; Eri: Eriodictyol; Vit: Vitexin.
Acknowledgements
References
Aslan, E., Guler, C., & Adem, S. (2015). In vitro effects of some flavonoids and phenolic acids on human pyruvate kinase isoenzyme M2. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(2), 314–317. https://doi.org/10.3109/14756366.2015.1022173
Shan, S., Shi, J., Yang, P., Jia, B., Wu, H., Zhang, X., & Li, Z. (2017). Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. Journal of Agricultural and Food Chemistry, 65(37), 8136–8144. https://doi.org/10.1021/acs.jafc.7b02757
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