Figure 2. Diurnal regulation of small intestinal REG3γ secretion.
Description
In response to feeding rhythms, SFB and Lactobacillus spp activate TLR-MyD88-IL22 pathways, thereby leading to REG3γ secretion by SI epithelial cells. In turn, REG3γ inhibits the expansion of luminal microbes and mucosal-associated bacteria. Diurnal consumption of food and microbial oscillations, in turn, influence the diurnal activity of the host, such as liver rhythmicity.
Acknowledgements
References
Karina Ratiner, Tahel Fachler-Sharp, & Eran Elinav. (2023). Small Intestinal Microbiota Oscillations, Host Effects and Regulation-A Zoom into Three Key Effector Molecules. Biology, 12(1), 142. https://doi.org/10.3390/biology12010142
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