Fibrotic Heart In Vitro Modelling
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
Myocardial infarction causes cardiomyocyte death and local remodeling of the extracellular matrix, leading to the progressive formation of a stiff fibrotic tissue mediated by profibrotic signals and mainly populated by cardiac fibroblasts. In vitro models of human pathological cardiac tissue that can reproduce the post-infarct microenvironment could greatly improve preclinical experimentation, helping in the selection of potential therapies for human heart regeneration.
Acknowledgements
References
González, A. (2018) Myocardial Interstitial Fibrosis in Heart Failure: Biological and Translational Perspectives. . J of the American College of Cardiology . https://pubmed.ncbi.nlm.nih.gov/29650126/
Veldhuizen, J. (2019) Three-dimensional microengineered models of human cardiac diseases. J Biol Eng . https://pubmed.ncbi.nlm.nih.gov/30988697/
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