Fibrinogen-Activated Microglia Contribute to Tissue Damage in Multiple Sclerosis
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
In multiple sclerosis (MS), fibrinogen that leaks through disrupted blood brain barrier binds to microglia and activates it. The activated microglia then secrets neurotoxic mediators which promote demyelination and neuronal degeneration.
Acknowledgements
References
Adams, R. A., Bauer, J., Flick, M. J., Sikorski, S. L., Nuriel, T., Lassmann, H., Degen, J. L., & Akassoglou, K. (2007). The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. The Journal of Experimental Medicine, 204(3), 571–582.
https://doi.org/10.1084/jem.20061931
Ryu, J. K., Davalos, D., & Akassoglou, K. (2009). Fibrinogen signal transduction in the nervous system. Journal of Thrombosis and Haemostasis, 7, 151–154.
https://doi.org/10.1111/j.1538-7836.2009.03438.x
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