Extracellular Matrix in Brain Tumorigenesis
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
The process tumorigenesis in the brain is accompanied by the remodeling of the extracellular matrix (ECM). ECM in the normal adult brain (left) is composed by proteoglycans (aggrecan, brevican), hyaluronic acid, tenascins (tenascin R) and collagen IV. In contrast, glioblastoma ECM (right) displays an increase in the overall density and stiffness, the absence of aggrecan, and the presence of neurodevelopmental proteins (tenascin C) and metalloproteases (MMPs), promoting invasion and angiogenesis.
Acknowledgements
References
Belousov, A. et. al.. (2019) The Extracellular Matrix and Biocompatible Materials in Glioblastoma Treatment. Front. Bioeng. Biotechnol.. https://www.frontiersin.org/articles/10.3389/fbioe.2019.00341/full
Dwywer, C. A.. (2011) The Neural Extracellular Matrix, Cell Adhesion Molecules and Proteolysis in Glioma Invasion and Tumorigenicity. Molecular Targets of CNS Tumors. https://www.semanticscholar.org/paper/The-Neural-Extracellular-Matrix%2C-Cell-Adhesion-and-Dwyer-Matthews/348ec20be6e51bba7fae74bf9133d84e58182ef2
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