Expression of PAZ domain of DCL1 alters miRNA biogenesis
Description
The processing of pri-miRNAs into premiRNAs is catalyzed by a complex composed of DCL1 and its functional partners HYPONASTICLEAVES1(HYL1),SERRATE(SE), and DAWDLE.The PIWI/ARGONAUTE/ZWILLE (PAZ) domain of DCL1 mediates the interaction with SE and DDL. We could disrupt the complex formation of DCL1, HYL1, SE, and DDL by overexpressing the synthetic microProtein designed from the PAZ domain of DCL1. As a consequence, the biogenesis of miRNAs should be affected
Acknowledgements
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