Ex-Vivo Lung Perfusion (EVLP): The Toronto Method
Description
In the Toronto method of ex-vivo lung perfusion (EVLP) the donor's lung is cannulated on the pulmonary artery and the atrial cuff. Oxygenated perfusate travels from the atrial cannula to the reservoir. The centrifugal pump then propels the perfusate through a deoxygenator and heat exchanger. Lastly, the perfusate returns through a leukocyte filter into the pulmonary cannula. EVLP serves as a platform to assess and potentially treat grafts with therapeutics prior to transplantation.
Acknowledgements
References
Cypel, M., Neyrinck, A. & Machuca, T.N. Ex vivo perfusion techniques: state of the art and potential applications. Intensive Care Med 45, 354–356 (2019). https://doi.org/10.1007/s00134-019-05568-3
Ku, T.J.; Cypel, M.; Ribeiro, R.V.; Ferreira, V.H.; Kumar, D.; Humar, A. (2019). Ex-Vivo Lung Perfusion Mediated Delivery of Rituximab to Clear Latent Epstein-Barr Virus. The Journal of Heart and Lung Transplantation, 38(4), S54–S55. doi:10.1016/j.healun.2019.01.119
Machuca, T. N., & Cypel, M. (2014). Ex vivo lung perfusion. Journal of thoracic disease, 6(8), 1054–1062. https://doi.org/10.3978/j.issn.2072-1439.2014.07.12
Pan, X., Yang, J., Fu, S., & Zhao, H. (2018). Application of ex vivo lung perfusion (EVLP) in lung transplantation. Journal of thoracic disease, 10(7), 4637–4642. https://doi.org/10.21037/jtd.2018.07.95
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