ER stress associated NLRP3 inflammasome activation in hippocampus of Alzheimer disease
Description
Activation of ER is crucial. This study focuses on ER stress and the TXNIP/NLRP3 inflammasome in AD neuroinflammation. Increased inflammasome components, along with some proteins (p-Tau, B-amyloid) worsen neuroinflammation in AD patients. The unfolded protein response (UPR) in AD shows elevated BiP and phosphorylated eIF2a, inhibiting translation and inducing CHOP-mediated apoptosis. TXNIP activation by ER stress links neuroinflammation, suggesting protein regulation in the AD hippocampus.
Acknowledgements
References
Ismael, S., Sakata, K., McDonald, M. P., Liao, F., & Ishrat, T. (2021). ER stress associated TXNIP-NLRP3 inflammasome activation in hippocampus of human Alzheimer's disease. Neurochemistry International, 148, 105104. https://doi.org/10.1016/j.neuint.2021.105104
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