Epithelial-mesenchymal transition (EMT) of Retinal Pigment Epithelial Cells (RPE)
Description
During Epithelial-mesenchymal transition (EMT) of Retinal Pigment Epithelial Cells (RPE), the once cuboidal, polarized and non-motile RPE cells transdifferentiate into spindle-shaped mesenchymal cells that have acquired migratory and contractile properties and secrete their own extracellular matrix proteins.
Acknowledgements
References
Shu DY, Butcher E, Saint-Geniez M. EMT and EndMT: Emerging Roles in Age-Related Macular Degeneration. Int J Mol Sci. 2020 Jun 16;21(12):4271. doi: 10.3390/ijms21124271. PMID: 32560057; PMCID: PMC7349630.
Shu DY, Butcher ER, Saint-Geniez M. Suppression of PGC-1α Drives Metabolic Dysfunction in TGFβ2-Induced EMT of Retinal Pigment Epithelial Cells. Int J Mol Sci. 2021 Apr 29;22(9):4701. doi: 10.3390/ijms22094701. PMID: 33946753; PMCID: PMC8124188.
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