Epigenetics and Gene Expression
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
Epigenetics can influence gene expression regulation through the deposition of of different histone marks. Histone acetylation, performed by Histone Acetyl Transferases (HATs) by using Acetyl-CoA as donor, leads to chromatin opening that allows RNAPII to bind to a promoter to induce target gene expression. Conversely, histone methylation, performed by Polycomb Repressive Complex 2 (PRC2) by using SAM as donor, leads to chromatin closing and represses transcription by preventing RNAPII binding.
Acknowledgements
References
Andrew J Bannister. (2011) Regulation of chromatin by histone modifications. Cell Research . https://www.nature.com/articles/cr201122
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