Epigenetic regulation of GPER expression in the GIT smooth muscles of wild-type versus diabetic mice
Description
A pictorial summary of how epigenetic modifications (DNA hypermethylation and histone modifications) cause the downregulation of G-protein coupled estrogen receptor (GPER) expression in the gastrointestinal smooth muscles of type 2 diabetic mice compared to wild-type mice.
Acknowledgements
References
1. Muhammad, A., Forcados, G. E., Yusuf, A. P., Abubakar, M. B., Sadiq, I. Z., Elhussin, I., Siddique, M. A. T., Aminu, S., Suleiman, R. B., Abubakar, Y. S., Katsayal, B. S., Yates, C. C., & Mahavadi, S. (2022). Comparative G-Protein-Coupled Estrogen Receptor (GPER) Systems in Diabetic and Cancer Conditions: A Review. Molecules, 27(24), 8943. https://doi.org/10.3390/molecules27248943
2. Luo, J., & Liu, D. (2020). Does GPER Really Function as a G Protein-Coupled Estrogen Receptor in vivo? Frontiers in Endocrinology, 11. https://doi.org/10.3389/fendo.2020.00148
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