Epigenetic effect of butyrate
Description
Butyrate is a histone deacetylase (HDAC) inhibitor. Inhibition of HDAC activity leads to incresed acetylation of histones and causes histone hyperacetylation. Histone tail acetylation increases the accessibility of a gene to the transcriptional machinery by causing the DNA to loosely associate with the histone proteins. Histone deacetylation causes histone tails to become highly charged and cause DNA to tightly bind to histones, so it becomes less accessible for transcription.
Acknowledgements
References
Berni Canani, R., Di Costanzo, M., & Leone, L. (2012). The epigenetic effects of butyrate: potential therapeutic implications for clinical practice. Clinical epigenetics, 4(1), 4. https://doi.org/10.1186/1868-7083-4-4
Liu, H., Wang, J., He, T., Becker, S., Zhang, G., Li, D., & Ma, X. (2018). Butyrate: A Double-Edged Sword for Health?. Advances in nutrition (Bethesda, Md.), 9(1), 21–29. https://doi.org/10.1093/advances/nmx009
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