Epigenetic changes during aging
Description
During aging DNA methylation increases at CpG islands but reduces in CpG-poor regions and endogenous retroviral (ERV) regions, resulting in less expression of housekeeping genes and the resurrection of ERVs. During aging the nuclear lamina erodes, making attached heterochromatin unstable. Also, a reduction in repressive histone markers and an increase in active histone markers and histone variant H3.3 cause increased chromatin accessibility and the expression of unwanted genes during aging.
Acknowledgements
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