Embryonic Migration of Neuronal Progenitors Relies on Astrocytic Scaffold

Description

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Neuronal intermediate progenitor (IP) migration during embryonic development is necessary for achieving correct brain cytoarchitecture. Radial glial cells (RGCs) basal process play a major role in this process. Early arising astrocytic progenitors, generated by RGCs after their switch from neurogenesis to gliogenesis, also appear to be involved. Conditional deletion of the gliogenic gene Sox9 shows that delayed formation of astrocyte progenitors affects neuronal migration.

Acknowledgements

References

Scott, C et al.. (2010) SOX9 induces and maintains neural stem cells.. https://www.ncbi.nlm.nih.gov/pubmed/20871603 Kang, P. et al.. (2012) Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. https://www.ncbi.nlm.nih.gov/pubmed/22500632 Barry, G. et al.. (2008) Specific glial populations regulate hippocampal morphogenesis. https://www.ncbi.nlm.nih.gov/pubmed/19020026

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