Drug-induced Cardiotoxicity
Description
Drug-induced cardiotoxicity refers to the detrimental effects on the cardiovascular system caused by certain drugs. It involves the alteration of contractility, molecular processes, and vasculature, leading to cardiac dysfunction. Cardiotoxicity can result from interactions between medications and cardiac receptors, channels, or proteins, which may inhibit enzymatic activity, vesicle trafficking, or disrupt signaling pathways. Understanding the mechanisms of drug-induced cardiotoxicity is essential for safe drug development and optimizing pharmacokinetics and pharmacodynamics.
[Template description adapted from GPT3.5, 2023]
Acknowledgements
References
Mamoshina, P., Rodriguez, B., & Bueno-Orovio, A. (2021). Toward a broader view of mechanisms of drug cardiotoxicity. Cell reports. Medicine, 2(3), 100216. https://doi.org/10.1016/j.xcrm.2021.100216
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