Drug Delivery in Rheumatoid Arthritis

Description

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. To treat rheumatoid arthritis, nanotechnology-based drug delivery systems have been developed to effectively improve therapeutic efficacy over free drugs. Nanoparticles such as dendrimers, polymeric micelles, and solid lipid nanoparticles loaded with anti-arthritic drugs (such as NSAIDs, DMARDs, corticosteroids and biologics) are normally administered orally, through intravenous or intra-articular injection or via transdermal delivery.

Acknowledgements

References

Qi R. (2015) Folate receptor-targeted dendrimer-methotrexate conjugate for inflammatory arthritis. J. Biomed. Nanotechnol. https://www.ncbi.nlm.nih.gov/pubmed/26295143 Arora R. (2015) Curcumin loaded solid lipid nanoparticles ameliorate adjuvant-induced arthritis in rats. Eur. J. Pain. https://www.ncbi.nlm.nih.gov/pubmed/25400173 Wang Y. (2019) Enhanced therapeutic effect of RGD-modified polymeric micelles loaded with low-dose methotrexate and nimesulide on rheumatoid arthritis. Theranostics. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376478/ Khurana S. (2013) Preparation and evaluation of solid lipid nanoparticles based nanogel for dermal delivery of meloxicam. Chem. Phys. Lipids. https://www.ncbi.nlm.nih.gov/pubmed/23994283

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