Dopamine's PKA/cAMP pathway intracellular signaling cascade
Description
This template ilustrates one of dopamine's various intracellular signaling cascades, the PKA/cAMP pathway.
Dopamine is synthesized from tyrosine and the tyrosine hydroxylase (TH) enzyme is the limiting enzyme of the process. When dopamine is released into the synaptic cleft, it can interact with its receptors and depending on the activated receptor, the cellular response may propagate or not.
Acknowledgements
References
Bibb, J., Snyder, G., Nishi, A. et al. (1999) Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature, 402, 669–671. https://doi.org/10.1038/45251
Carlezon W. A., Duman, R., & Nestler, E. (2005). The many faces of CREB. Trends in Neurosciences, 28(8), 436–445. https://doi.org/10.1016/j.tins.2005.06.005
Girault, J. A., & Greengard, P. (2004). The Neurobiology of Dopamine Signaling. ARCH NEUROL, 61, 641-645.
Nestler, E. J. (2013). ΔFosB: A Molecular Switch for Reward. Journal of Drug and Alcohol Research, 2, 1–11. https://doi.org/10.4303/jdar/235651
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