Development of cervical cancer
Description
After entry into cells, the expression of the E1 and E2 genes maintain a low number of copies of the virus genome. The E6 and E7 oncoproteins act to increase cell proliferation. The late region of the genome encodes the L1 and L2 structural proteins that make up the capsid protein, and protect the viral genome located inside. The progression of HPV-infected epithelial cells to invasive cancer is a long-term process associated with the accumulation of DNA changes in host cell genes.
Acknowledgements
References
Bouvard, V., Wentzensen, N., Mackie, A., Berkhof, J., Brotherton, J., Giorgi-Rossi, P., ... & Lauby-Secretan, B. (2021). The IARC perspective on cervical cancer screening. New England Journal of Medicine, 385(20), 1908-1918.
Della Fera, A. N., Warburton, A., Coursey, T. L., Khurana, S., & McBride, A. A. (2021). Persistent human papillomavirus infection. Viruses, 13(2), 321.
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