Developing a 3D ex vivo Peripheral Nerve Injury model
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
This figure depicts the development of a 3D ex vivo fiber testing model that replicates a peripheral nerve injury. This model can be used to test new materials for peripheral nerve repair. Nerve guide conduits (NGCs) are 3D printed and fibers manufactured by electrospinning are threaded into NGCs. Dorsal root ganglia are dissected and explanted on top of the NGC. The NGCs and DRGs are incubated in cell culture medium for 21 days. Fibers can then be removed, immunolabelled with specific cell antigens and imaged with confocal microscopy for analysis.
Acknowledgements
References
Behbehani, M. (2018) Pre-clinical evaluation of advanced nerve guide conduits using a novel 3D in vitro testing model. International Journal of Bioprinting. https://doi.org/10.18063/IJB.v4i1.123
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