Cysteine protease Cathepsins roles in promoting cancer (scheme)
Description
Tumorigenesis is promoted by Cathepsin E, F, G and Z. Proliferation by B, D, E, X, while X mediates EMT. Dissemination is induced by A, B, D. ECM proteins degradation by B, K, L and Z. During migration, motility and invasion is increased by B, D, H, L, S, and Z Cathepsins, which induces the tumor cells to invade surrounding tissue, blood- and lymph vessels in general an increased ability to metastasize. Newly formed tumor proliferation and angiogenesis is mediated by B, D, H, and S.
Acknowledgements
References
Tan GJ, Peng ZK, Lu JP, Tang FQ. Cathepsins mediate tumor metastasis. World J Biol Chem. 26. november 2013;4(4):91–101.
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