Crosstalk Between Apoptosis & Autophagy
Description
Apoptosis and autophagy intertwine. DNA damage-induced P53 activation induces apoptosis and inhibits autophagy. Apoptosis can trigger/impede autophagy based on cell state. Mitochondrial disruption prompts apoptosis, affecting destiny. Few affected mitochondria activate autophagy, ensuring survival. More lead to apoptosis. Majority cause necrosis. Caspases activate/suppress autophagy. Autophagy reciprocally regulates apoptosis. Post-apoptosis, phosphatidylserine exposure signals autophagy.
Acknowledgements
References
Izadi, M.; Ali, T.A.; Pourkarimi, E. Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy. Int. J. Mol. Sci. 2021, 22, 12466. https://doi.org/10.3390/ijms222212466
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