CRISPR-Cas9 Adaptive Immune System of Streptococcus pyogenes Against Bacteriophages
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
The CRISPR-Cas9 system confers bacteria with adaptive immunity against invading bacteriophages. Once infected, Cas1 and Cas2 incorporate a short segment of viral genome as spacers within the CRISPR locus of the bacterial genome. Upon reinfection with the same bacteriophage, the CRISPR locus is expressed as pre-CRNA, along with tracrRNA. This pre-crRNA is processed to yield guide RNAs (gRNAs) which bind the ribonucleoprotein, Cas9 as well as complementary segments of the invading virus genome, prompting its cleavage by Cas9.
Acknowledgements
References
A. Le Rhun et al. . (2019) CRISPR-Cas in Streptococcus pyogenes . RNA Biology . https://doi.org/10.1080/15476286.2019.1582974
K. Murugan et al.. (2017) The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit. Molecular Cell . https://doi.org/10.1016/j.molcel.2017.09.007
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