Complex I specific activity is reduced in neurodegeneration
Description
Complex I specific activity within the electron transport chain (ETC) is found to be up to 40% decreased in some neurodegenerative diseases. This leads to both reduced electron flow through the ETC as well as reduced mitochondrial membrane potential. This consequently reduces ATP production as well as increases reactive oxygen species production (ROS). Mitochondria are dysfunctional in neurodegenerative diseases and complex I inhibition likely significantly contributes to this.
Acknowledgements
References
1. Pollard, A. K., Craig, E. L., & Chakrabarti, L. (2016). Mitochondrial complex 1 activity measured by spectrophotometry is reduced across all brain regions in ageing and more specifically in neurodegeneration. PLoS One, 11(6), e0157405.
2. Kilbride, S. M., Telford, J. E., & Davey, G. P. (2021). Complex I controls mitochondrial and plasma membrane potentials in nerve terminals. Neurochemical Research, 46, 100-107.
3. Zhao, R. Z., Jiang, S., Zhang, L., & Yu, Z. B. (2019). Mitochondrial electron transport chain, ROS generation and uncoupling. International journal of molecular medicine, 44(1), 3-15.
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