Complement System Role in Opsonization and Phagocytosis
Description
One way for complement-mediated microbial destruction involves opsonization to enhance phagocytosis. This starts with complement components, specifically C3, binding to bacteria as C3b or iC3b. These proteins interact with complement receptors (CRs) present on phagocytes, triggering their activation. This initiates bacterial ingestion, respiratory burst production, and ultimately, bacterial elimination.
Acknowledgements
References
Dunkelberger, J. R., & Song, W. C. (2010). Complement and its role in innate and adaptive immune responses. Cell research, 20(1), 34-50.
Vandendriessche, S., Cambier, S., Proost, P., & Marques, P. E. (2021). Complement receptors and their role in leukocyte recruitment and phagocytosis. Frontiers in Cell and Developmental Biology, 9, 624025.
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