Cleavage of Amyloid Precursor Protein (APP)
Description
The figure summarizes the normal and abnormal cleavage of amyloid precursor protein (APP). This abnormal cleavage depicts the formation of a sticky neurotoxic A-beta which then gets accumulated as plaques in the extracellular space.
Acknowledgements
References
Patterson, C., Feightner, J. W., Garcia, A., Hsiung, G.-Y. R., MacKnight, C., & Sadovnick, A. D. (2008). Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease. CMAJ, 178(5), 548–556. https://doi.org/10.1503/cmaj.070796
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