Cholinergic interneurons integrate striatal signals

Description

Within the striatum, cholinergic interneurons (CINs) integrate a massive number of signals including information from outside the striatum (cortex, substantia nigra pars compacta, and thalamus) and from within. Through these connections, CINs also regulate the activity of other striatal neurons through cholinergic signaling.

Acknowledgements

References

Poppi, L. A., Ho-Nguyen, K. T., Shi, A., Daut, C. T., & Tischfield, M. A. (2021). Recurrent implication of striatal cholinergic interneurons in a range of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. Cells, 10(4), 907. Lim, S. A. O., Kang, U. J., & McGehee, D. S. (2014). Striatal cholinergic interneuron regulation and circuit effects. Frontiers in synaptic neuroscience, 6, 22. Abudukeyoumu, N., Hernandez‐Flores, T., Garcia‐Munoz, M., & Arbuthnott, G. W. (2019). Cholinergic modulation of striatal microcircuits. European Journal of Neuroscience, 49(5), 604-622. Kawaguchi, Y., Wilson, C. J., Augood, S. J., & Emson, P. C. (1995). Striatal interneurones: chemical, physiological and morphological characterization. Trends in neurosciences, 18(12), 527-535.

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