Chemogenetics in the Treatment of Stroke
Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
This figure summarizes the findings from Wang et al. (2020). The group found that the Cre-mediated expression of hM4Di, a Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic receptor, inhibits the activity of forebrain excitatory neurons and leads to improved stroke outcome.
Acknowledgements
References
Wang, Y., Galeffi, F., Wang, W., Li, X., Lu, L., Sheng, H., Hoffmann, U., Turner, D. A., & Yang, W. (2020). Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome. Experimental Neurology, 326, 113206. https://doi.org/10.1016/j.expneurol.2020.113206
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