Characterization of Coexisting Interaction Between P. aeruginosa and S. aureus

Description

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Co-infecting strains of P. aeruginosa and S. aureus are isolated from a single sputum recovered from Cystic fibrosis patients. Competition tests on plates highlight bacterial competition when P. aeruginosa inhibits S. aureus growth. Otherwise, both pathogens can coexist. Distinctive features of coexistence are assessed by comparing gene expression, survival, carbon catabolism and antibiotic resistance of both bacteria during co-cultures and monocultures.

Acknowledgements

References

Briaud et. al.. (2019) Coexistence With Pseudomonas Aeruginosa Alters Staphylococcus Aureus Transcriptome, Antibiotic Resistance and Internalization Into Epithelial Cells . Scientific Reports. https://www.nature.com/articles/s41598-019-52975-z Briaud et. al.. (2020) Impact of Coexistence Phenotype Between Staphylococcus aureus and Pseudomonas aeruginosa Isolates on Clinical Outcomes Among Cystic Fibrosis Patients. Front. Cell. Infect. Microbiol.. https://www.frontiersin.org/articles/10.3389/fcimb.2020.00266/full#supplementary-material Baldan et. al.. (2014) Adaptation of Pseudomonas aeruginosa in Cystic Fibrosis Airways Influences Virulence of Staphylococcus aureus In Vitro and Murine Models of Co-Infection. PLoS One. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945726/ Camus et. al.. (2020) Trophic cooperation promotes bacterial survival of Staphylococcus aureus and Pseudomonas aeruginosa. (in revision)

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