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This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. The limited success of CAR T-cell therapy in solid tumors can be accounted to many challenges, including: (1) the heterogeneous expression of tumor-associated antigens (TAA), leading to outgrowth of antigen-negative tumor variants; (2) inefficient trafficking of CAR T cells to tumor sites and (3) the metabolically hostile tumor microenvironment that includes the presence of immunosuppressive molecules (TGFb, IL-10, etc) and cells (T-regs, MDSCs, etc) and can lead to CAR T-cell exhaustion.