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An editable high resolution scientific image depicting CD40 Ligand Deficiency

CD40 Ligand Deficiency

Description

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. The interaction of CD40 and CD40L on B and T cells, respectively, is crucial for B cell immunoglobulin class switching. Upon successful signaling, B cells proliferate and undergo class switching to either IgG, IgA, IgE, IgD, or IgM, depending on the antigen. However, in patients with CD40L deficiency, B cells cannot undergo class switching, leading to an excessive amount of IgM production (hyper IgM syndrome).

Acknowledgements

References

Amos Etzioni. (2004) The Hyper IgM Syndrome—An Evolving Story. Pediatric Research / Nature. https://www.nature.com/articles/pr2004508
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