Calcium Homeostasis in a Mammalian Cell

Description

Calcium homeostasis is tightly regulated by a network of mechanisms. Receptor operated and voltage-gated Ca channels, facilitate Ca entry, while Na-Ca exchanger and plasma membrane Ca ATPase regulate Ca efflux. Inside the cell Ca is sequestered into sarcoplasmic/ER by SERCA pump. Intracellular Ca release is mediated by inositol triphosphate and ryanodine receptors. This system maintains Ca levels within a narrow range, crucial for cellular functions and signaling.

Acknowledgements

BioRender (2022). Cellular Environment (Background).

References

Mei Y, Thompson MD, Cohen RA, Tong X. Endoplasmic Reticulum Stress and Related Pathological Processes. J Pharmacol Biomed Anal. 2013 Nov 15;1(2):1000107. PMID: 24611136; PMCID: PMC3942890. Stafford N, Wilson C, Oceandy D, Neyses L, Cartwright EJ. The Plasma Membrane Calcium ATPases and Their Role as Major New Players in Human Disease. Physiol Rev. 2017 Jul 1;97(3):1089-1125. doi: 10.1152/physrev.00028.2016. PMID: 28566538.

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