Botulinum Toxin A Effect in Neuromuscular Junction
Description
Botulinum toxin A, produced by anaerobic bacteria Clostridium botulinum, blocks the release of acetylcholine from the axon terminal. The botulinum toxin cleaves specific soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) proteins that are essential for binding and fusion of the synaptic vesicles with the presynaptic membrane.
Acknowledgements
References
Ross, M. H., & Pawlina, W. (2018). Histology: A Text and Atlas (8th ed.). Philadelphia, PA: Wolters Kluwer Health/Lippincott Williams & Wilkins.
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