Biomarkers of response and resistance to immune checkpoint blockers
Description
Response markers (blue boxes) are those whose presence or significant quantity before treatment (* or whose concentrations change during treatment) are associated with a response, and vice versa for resistance markers (red boxes). They are sub-categorised according to their location:
in the bloodstream ("BLOOD"), the tumour or tumour microenvironment ("TUMOR") or in the intestinal microbiota.
Acknowledgements
References
Duchemann B, Remon J, Naigeon M, Cassard L, Jouniaux JM, Boselli L, Grivel J, Auclin E, Desnoyer A, Besse B, Chaput N. Current and future biomarkers for outcomes with immunotherapy in non-small cell lung cancer. Transl Lung Cancer Res. 2021 Jun;10(6):2937-2954. doi: 10.21037/tlcr-20-839. PMID: 34295689; PMCID: PMC8264336.
Duchemann B, Remon J, Naigeon M, Mezquita L, Ferrara R, Cassard L, Jouniaux JM, Boselli L, Grivel J, Auclin E, Desnoyer A, Besse B, Chaput N. Integrating Circulating Biomarkers in the Immune Checkpoint Inhibitor Treatment in Lung Cancer. Cancers (Basel). 2020 Dec 3;12(12):3625. doi: 10.3390/cancers12123625. PMID: 33287347; PMCID: PMC7761725.
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