Biogenesis, functions, and transportation of miRNAs.
Description
1. Endosomes can uptake mature miRNAs encapsulated in small vesicles and develop into multivesicular bodies (MVBs). Through exocytosis, the vesicles inside MVBs are released into extracellular space. 2. Plasma membrane budding encapsulates miRNAs near the membrane and releases them into the extracellular space. 3. RNA binding proteins, such as Ago and lipoprotein, bind to mature miRNAs and pass through the cell membrane into extracellular space.
Acknowledgements
References
Chang C, Wang Y, Wang R, Bao X. Considering Context-Specific microRNAs in Ischemic Stroke with Three "W": Where, When, and What. Mol Neurobiol. Published online February 21, 2024. doi:10.1007/s12035-024-04051-5
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